PERBANDINGAN SENSITIVITAS AMOXICILLIN DAN ERITROMICIN TERHADAP STREPTOCOCCUS β - HEMOLYTICUS PADA PEROKOK

KARINA RAMADHANI; ANCE ROSLINA

KARINA RAMADHANI UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
ANCE ROSLINA UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Keywords: Amoxicillin, Eritromicin, Smoker, Streptococcus β-Hemolyticus

Abstract

Active smokers and those who have been exposed to cigarette smoke are at high risk for bacterial infection. Exposure to
tobacco smoke in these cigarettes can increase the susceptibility of upper respiratory tract infections. Knowing the
comparative sensitivity of amoxicillin and erythromycin Streptococcus β-hemolyticus in smokers. Research using
observational analytic methods. The sample of this study approved 25 samples that met the inclusion criteria determined by
purposive sampling. Data analysis in this study used non-parametric statistics with multivariate analysis with the Wilcoxon
test. The average sensitivity of the antibiotic amoxicillin was 17.7188 and the sensitivity of the erythromycin antibiotic was
16.7012 with a difference of sensitivity of 1.0176. Wilcoxon test results p = 0.619 (> 0.05) which means there is no significant
difference in the sensitivity of the use of antibiotics amoxicillin and erythromycin against Streptococcus β-hemolyticus
bacteria in smokers. There was no significant effect on the use of the antibiotic amoxicillin and erythromycin on Streptococcus
β-hemolyticus in smokers.

References

Batubara IVD, Wantouw B, Tendean L. Pengaruh Paparan Asap Rokok Kretek Terhadap Kualitas Spermatozoa Mencit
Jantan (Mus Musculus). e- Biomedik (eBM). 2013;1:330-337.
Kementrian Kesehatan RI. Riset Kesehatan Dasar. 2013.
Bagaitkar J, Demuth D, Scott D. Tobacco use increases susceptibility to bacterial infection. Tob Induc Dis. 2008;4(1).
Agna S, Budi S, Waty W. Prevalensi Streptococcus Beta- Hemolyticus Group A pad Apus Tenggorok Mahasiswa Fakultas
Kedokteran Gigi Universitas Kristen Maranatha Tahun 2014. JuKe Unila.2014.
Elliot T et al. Mikrobiologi Kedokteran & Infeksi. 4th ed. EGC; 2013.
Soleha TU. Uji Kepekaan terhadap Antibiotik. JuKe Unila. 2015;5:3-7.
Kiran S, Sharma P, Harjai K, Capalash N. Enzymatic quorum quenching increases antibiotic susceptibility of multidrug
resistant Pseudomonas aeruginosa. 2011;3(1):1-12.
Asriadi. Uji Sensitivitas Beberapa Antibiotik terhadap Bakteri Penyebab Infeksi Saluran Pernapasan Atas (ISPA) di RSUD
Syech Yusuf Kab. Gowa. 2012.
Yeung WS, Sahota SD, Leung YT. Comparison of the effect of penicillins versus erythromycin in preventing neonatal groupB
streptococcus infection in active carriers following preterm prelabor rupture of membranes. Taiwan J Obstet Gynecol.
2014;53:210-214.
Zakharian G, Sukrama DM, Nengah N, Fatmawati D. Pemberian antibiotik cefotaxime dengan konsentrasi sublethal pada
isolat Klebsiella pnuemoniae yang resisten terhadap ampicilin menginduksi Multi Drug Resisten (MDR). 2018;9(1):64-70.