HUBUNGAN FAKTOR RISIKO DENGAN TIPE HISTOPATOLOGI KANKER ENDOMETRIUM DI BEBERAPA RUMAH SAKIT KOTA MEDAN TAHUN 2015 – 2018
Keywords:
Type, Histopathology, Endometrial Cancer, Risk Factors
Abstract
Endometrial cancer is gynecological cancer. Endometrial cancer is classified into type I and type II. Several factors have
been linked to an increased risk of endometrial cancer. The relationship between age, parity, history of hypertension, obesity,
age of menarche, and a history of infertility for endometrial cancer are controversial from several studies. This research
method is an analytic observational study with a cross-sectional study. Research subjects were 31 cases of endometrial
cancer diagnosed and registered in Dr Pirngadi Medan Hospital and Medan Haji Hospital in 2015-2018 that met the inclusion
and exclusion criteria. The sampling technique uses total sampling. There are effects of age, parity, duration of use of
hormonal contraception, history of diabetes, history of hypertension, obesity, age of menarche and history of infertility with
histopathological type of endometrial cancer. All variables have the same strong relationship with the histopathological type
of endometrial cancer.
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of
incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.
Khazaei Z, Dehkordi AH, Amiri M, et al. The incidence and Mortality of endometrial cancer and its association with body
mass index and human development index in asian population. 2018;5(4).
Dewi PPP, Budiana I nyoman G. Profil Pasien Kanker Endometrium Di RSUP Sanglah Denpasar Periode Agustus 2012-Juli
2014. E-Jurnal Med. 2017;6(8):1-7.
Bermudez A, Bhatla N, Leung E. International Journal of Gynecology and Obstetrics Cancer of the cervix uteri. Int J Gynecol
Obstet. 2015;131(December):S88-S95.
Conklin CMJ, Longacre TA. Lynch syndrome in endometrial carcinoma: A sentinel diagnosis. Pathol Case Rev.
2014;19(2):78-84.
Kamal A, Tempest N, Parkes C, et al. Hormones and endometrial carcinogenesis. Horm Mol Biol Clin Investig.
2016;25(2):129-148.
Ding D-C, Chen W, Wang J-H, Lin S-Z. Association between polycystic ovarian syndrome and endometrial, ovarian, and
breast cancer. Medicine (Baltimore). 2018;97(39):e12608.
Cote ML, Alhajj T, Ruterbusch JJ, et al. Risk factors for endometrial cancer in black and white women: a pooled analysis
from the epidemiology of endometrial cancer consortium (E2C2). Cancer Causes Control. 2015;26(2):287-296.
Colombo N, Creutzberg C, Amant F, et al. ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis,
treatment and follow-up. Radiother Oncol. 2015;117(3):559- 581.
Felix AS, Yang HP, Gierach GL, Park Y, Brinton LA. Cigarette smoking and endometrial carcinoma risk: The role of effect
modification and tumor heterogeneity. Cancer Causes Control. 2014;25(4):479-489.
Aziz MF. Gynecological cancer in Indonesia. J Gynecol Oncol. 2009;20(1):8-10.
Open Database: WHO’S Certified [database on The Internet].GLOBOCAN: Corpus uteri. c2018-[cited 2019 Aug 12].
Available from: http://gco.iarc.fr/today/data/factsheets/ populations/266-gabon-fact-sheets.pdf
Sheikh MA, Althouse AD, Freese KE, et al. USA Endometrial Cancer Projections to 2030 : Should we be concerned ? Futur
Oncol. 2014;10(16):2561-2568.
Tulumang JA, Loho MF, Mamengko LM. Gambaran Kanker Endometrium yang Dirawat di RSUP Prof. Dr. R. D. Kandou
Manado Periode 2013-2015. J e-Clinic. 2016;4(1).
Rosen MW, Tasset J, Kobernik EK, Smith YR, Johnston C, Quint EH. Risk Factors for Endometrial Cancer or Hyperplasia in
Adolescents and Women 25 Years Old or Younger. J Pediatr Adolesc Gynecol. 2019;32(5):546-549.
Michels KA, Pfeiffer RM, Brinton LA, Trabert B. Modification of the associations between duration of oral contraceptive use
and ovarian, endometrial, breast, and colorectal cancers. JAMA Oncol. 2018;4(4):516- 521.
Nevadunsky NS, Van Arsdale A, Strickler HD, et al. Obesity and age at diagnosis of endometrial cancer. Obstet Gynecol.
2014;124(2 PART1):300- 306.
He Y, Tao X, Huang F, et al. Clinicopathologic features of endometrial cancer in Chinese patients younger than 50 years with
a family history of cancer. Med (United States). 2018;97(43).
Setiawan VW, et al. Age the last birth in relation risk of endomterial cancer: pooled analysis the epidemiology of endometrial
cancer consortium. American Journal of Epidemiology. 2012;176(4).
Jezan HS, Kutb MA. Histopathological variations of endometrial carcinoma. International Journal of Science and Healthcare
Research. 2019;4(4).
Leslie KK, Thiel KW, Goodheart MJ, et.al,. Endometrial cancer. Obstet Gynecol Clin North Am. 2012;39(2):255–268.
Constantine GD, Kessler G, Graham S, et.al,. Increased incidence of endometrial cancer following the women's health
initiative: An Assessment of Risk Factors. J Womens Health (Larchmt). 2019;28(2):237– 243.
Alghamdi IG, Hussain II, Alghamdi MS, et.al,. The incidence rate of corpus uteri cancer among females in Saudi Arabia: an
observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Int J Womens Health.
2014;6:141–147.
American Institute for Cancer Research. Endometrial Cancer. Report. world cancer research fund global network. 2013.
Available from http://www.aicr.org/assets/docs/pdf/re ports/2013-cup-endometrial- cancer.pdf
Wirdayana M. Hubungan indeks massa tubuh dan jumlah paritas dengan derajat histopatologis kanker endometrium tipe I di
RSUP H. Adam Malik periode 2012-2015. Skripsi, Universitas Sumatera Utara. 2016.
Qonita W, Islimsyaf AS, Aditiyono. Hubungan hiperplasia endometrium dengan mioma uteri studi kasus pada pasien
ginekologi RSUD Prof.dr.margono soekardjo purwokerto. Majalah of health. 2011;5(3).
American Cancer Society. Endometrial (uterine) cancer. 2012. Available fromhttp://www.cancer.org/acs/groups/cid/doc
uments/webcontent/003097- pdf.pdf
Dossus L, Allen N, Kaaks R, Bakken R, Lund E, Tjonneland A, Olsen A, Overvad K. dkk. Reproductive risk factors and
endometrial cancer: the European prospective investigation into cancer and nutrition. International Journal of Cancer.
2010;127(2):442- 451.
Rota M, Rumi F, Bagnardi V, Dal Maso L, Zucchetto A, Levi F, et al. Modelling body mass index and endometrial cancer risk
in a pooled analysis of three case-control studies [present Special Issue]. BJOG. 2015.
Crosbie EJ, Zwahlen M, Kitchener HC, Egger M, Renehan AG. Body mass index, hormone replacement therapy, and
endometrial cancer risk: a meta- analysis. Cancer Epidemiol Biomarkers Prev. 2010;19:3119–30.
Fader AN, Frasure HE, Gil KM, Berger NA, von Gruenigen VE. Quality of life in endometrial cancer survivors: what does
obesity have to do with it? Obstet Gynecol Int. 2011:308-609.
Cirillo PM, Wang ET, Cedars MI, Chen LM, Cohn BA. Irreguler menses predicts ovarian cancer: prospective evidence from
child health and deveopment studies. International Journal of Cancer. 2016;139(1):1009- 17.
Perez k, Ernstoff LT, Cramer DW, Harlow BL, Baron JA, Greenberg ER, Dkk. Menstrual and reproductive factors in relation
to ovarian cancer risk. British Journal of Cancer. 2001;4(5):714-21.
Yang HP, Weiderpass LSC, Adami HO, Anderson KE, et al. Infertility and incident endometrial cancer risk: a pooled analysis
from the epidemiology of endometrial cancer consortium (E2C2). British Journal of Cancer. 2015;112:925-933.
incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.
Khazaei Z, Dehkordi AH, Amiri M, et al. The incidence and Mortality of endometrial cancer and its association with body
mass index and human development index in asian population. 2018;5(4).
Dewi PPP, Budiana I nyoman G. Profil Pasien Kanker Endometrium Di RSUP Sanglah Denpasar Periode Agustus 2012-Juli
2014. E-Jurnal Med. 2017;6(8):1-7.
Bermudez A, Bhatla N, Leung E. International Journal of Gynecology and Obstetrics Cancer of the cervix uteri. Int J Gynecol
Obstet. 2015;131(December):S88-S95.
Conklin CMJ, Longacre TA. Lynch syndrome in endometrial carcinoma: A sentinel diagnosis. Pathol Case Rev.
2014;19(2):78-84.
Kamal A, Tempest N, Parkes C, et al. Hormones and endometrial carcinogenesis. Horm Mol Biol Clin Investig.
2016;25(2):129-148.
Ding D-C, Chen W, Wang J-H, Lin S-Z. Association between polycystic ovarian syndrome and endometrial, ovarian, and
breast cancer. Medicine (Baltimore). 2018;97(39):e12608.
Cote ML, Alhajj T, Ruterbusch JJ, et al. Risk factors for endometrial cancer in black and white women: a pooled analysis
from the epidemiology of endometrial cancer consortium (E2C2). Cancer Causes Control. 2015;26(2):287-296.
Colombo N, Creutzberg C, Amant F, et al. ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis,
treatment and follow-up. Radiother Oncol. 2015;117(3):559- 581.
Felix AS, Yang HP, Gierach GL, Park Y, Brinton LA. Cigarette smoking and endometrial carcinoma risk: The role of effect
modification and tumor heterogeneity. Cancer Causes Control. 2014;25(4):479-489.
Aziz MF. Gynecological cancer in Indonesia. J Gynecol Oncol. 2009;20(1):8-10.
Open Database: WHO’S Certified [database on The Internet].GLOBOCAN: Corpus uteri. c2018-[cited 2019 Aug 12].
Available from: http://gco.iarc.fr/today/data/factsheets/ populations/266-gabon-fact-sheets.pdf
Sheikh MA, Althouse AD, Freese KE, et al. USA Endometrial Cancer Projections to 2030 : Should we be concerned ? Futur
Oncol. 2014;10(16):2561-2568.
Tulumang JA, Loho MF, Mamengko LM. Gambaran Kanker Endometrium yang Dirawat di RSUP Prof. Dr. R. D. Kandou
Manado Periode 2013-2015. J e-Clinic. 2016;4(1).
Rosen MW, Tasset J, Kobernik EK, Smith YR, Johnston C, Quint EH. Risk Factors for Endometrial Cancer or Hyperplasia in
Adolescents and Women 25 Years Old or Younger. J Pediatr Adolesc Gynecol. 2019;32(5):546-549.
Michels KA, Pfeiffer RM, Brinton LA, Trabert B. Modification of the associations between duration of oral contraceptive use
and ovarian, endometrial, breast, and colorectal cancers. JAMA Oncol. 2018;4(4):516- 521.
Nevadunsky NS, Van Arsdale A, Strickler HD, et al. Obesity and age at diagnosis of endometrial cancer. Obstet Gynecol.
2014;124(2 PART1):300- 306.
He Y, Tao X, Huang F, et al. Clinicopathologic features of endometrial cancer in Chinese patients younger than 50 years with
a family history of cancer. Med (United States). 2018;97(43).
Setiawan VW, et al. Age the last birth in relation risk of endomterial cancer: pooled analysis the epidemiology of endometrial
cancer consortium. American Journal of Epidemiology. 2012;176(4).
Jezan HS, Kutb MA. Histopathological variations of endometrial carcinoma. International Journal of Science and Healthcare
Research. 2019;4(4).
Leslie KK, Thiel KW, Goodheart MJ, et.al,. Endometrial cancer. Obstet Gynecol Clin North Am. 2012;39(2):255–268.
Constantine GD, Kessler G, Graham S, et.al,. Increased incidence of endometrial cancer following the women's health
initiative: An Assessment of Risk Factors. J Womens Health (Larchmt). 2019;28(2):237– 243.
Alghamdi IG, Hussain II, Alghamdi MS, et.al,. The incidence rate of corpus uteri cancer among females in Saudi Arabia: an
observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Int J Womens Health.
2014;6:141–147.
American Institute for Cancer Research. Endometrial Cancer. Report. world cancer research fund global network. 2013.
Available from http://www.aicr.org/assets/docs/pdf/re ports/2013-cup-endometrial- cancer.pdf
Wirdayana M. Hubungan indeks massa tubuh dan jumlah paritas dengan derajat histopatologis kanker endometrium tipe I di
RSUP H. Adam Malik periode 2012-2015. Skripsi, Universitas Sumatera Utara. 2016.
Qonita W, Islimsyaf AS, Aditiyono. Hubungan hiperplasia endometrium dengan mioma uteri studi kasus pada pasien
ginekologi RSUD Prof.dr.margono soekardjo purwokerto. Majalah of health. 2011;5(3).
American Cancer Society. Endometrial (uterine) cancer. 2012. Available fromhttp://www.cancer.org/acs/groups/cid/doc
uments/webcontent/003097- pdf.pdf
Dossus L, Allen N, Kaaks R, Bakken R, Lund E, Tjonneland A, Olsen A, Overvad K. dkk. Reproductive risk factors and
endometrial cancer: the European prospective investigation into cancer and nutrition. International Journal of Cancer.
2010;127(2):442- 451.
Rota M, Rumi F, Bagnardi V, Dal Maso L, Zucchetto A, Levi F, et al. Modelling body mass index and endometrial cancer risk
in a pooled analysis of three case-control studies [present Special Issue]. BJOG. 2015.
Crosbie EJ, Zwahlen M, Kitchener HC, Egger M, Renehan AG. Body mass index, hormone replacement therapy, and
endometrial cancer risk: a meta- analysis. Cancer Epidemiol Biomarkers Prev. 2010;19:3119–30.
Fader AN, Frasure HE, Gil KM, Berger NA, von Gruenigen VE. Quality of life in endometrial cancer survivors: what does
obesity have to do with it? Obstet Gynecol Int. 2011:308-609.
Cirillo PM, Wang ET, Cedars MI, Chen LM, Cohn BA. Irreguler menses predicts ovarian cancer: prospective evidence from
child health and deveopment studies. International Journal of Cancer. 2016;139(1):1009- 17.
Perez k, Ernstoff LT, Cramer DW, Harlow BL, Baron JA, Greenberg ER, Dkk. Menstrual and reproductive factors in relation
to ovarian cancer risk. British Journal of Cancer. 2001;4(5):714-21.
Yang HP, Weiderpass LSC, Adami HO, Anderson KE, et al. Infertility and incident endometrial cancer risk: a pooled analysis
from the epidemiology of endometrial cancer consortium (E2C2). British Journal of Cancer. 2015;112:925-933.
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